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\"u40779328143610367406fm173app49fJPG\"<\/div>\n<\/div>\n
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\"u16473225251871530052fm173app49fJPG\"<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\"u101450430677146240fm173app49fJPG\"<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\"u11666840473524959123fm173app49fJPG\"<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\u6700\u540e\uff0c\u7814\u7a76\u56e2\u961f\u6784\u5efa\u6210\u5206\u9776\u5411\u901a\u8def\uff08component-target-pathway\uff09\uff0c\u901a\u8fc7\u7f51\u7edc\u836f\u7406\u5b66\u5206\u6790\u663e\u793a\uff0c\u8fde\u82b1\u6e05\u761f\u4e2d\u7684\u6210\u5206\u548c\u63d0\u9ad8\u4eba\u4f53\u514d\u75ab\u529b\u7684\u91cd\u8981\u901a\u8def\u76f8\u5173\uff0c\u4f8b\u5982T\u7ec6\u80de\u3001B\u7ec6\u80de\u53d7\u4f53\u4fe1\u53f7,\u81ea\u7136\u6740\u4f24\u7ec6\u80de\uff08NK\uff09\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\uff0c\u4ee5\u53ca\u6297\u708e\u901a\u8def\u5305\u62ecFc epsilon RI\u3001ErbB\u3001MAPK\u4fe1\u53f7\u7b49\u3002<\/span><\/p>\n

\n
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\"u4524948312379940376fm173app49fJPEG\"<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\u7814\u7a76\u56e2\u961f\u63d0\u5230\uff0c\u75c5\u6bd2\u6027\u80ba\u708e\u6d89\u53ca\u611f\u67d3\u3001\u708e\u75c7\u3001\u514d\u75ab\u3001\u51dd\u8840\u3001\u7ec4\u7ec7\u635f\u4f24\u548c\u9057\u4f20\u591a\u6001\u6027\u7b49\u591a\u4e2a\u8fc7\u7a0b\u3002\u4ed6\u4eec\u6307\u51fa\uff0c\u572810\u79cd\u708e\u75c7\u548c\u514d\u75ab\u4fe1\u53f7\u901a\u8def\u4e2d\uff0c\u7ea2\u666f\u5929\u7519\u3001\u82e6\u674f\u4ec1\u7519\u3001\u7350\u82bd\u83dc\u82f7\u3001\u5927\u9ec4\u7d20-8-O-\u03b2-D-\u8461\u8404\u7cd6\u82f7\u3001\u8292\u67c4\u82b1\u9ec4\u7d20\u3001\u7eff\u539f\u9178\u3001\u91d1\u4e1d\u6843\u82f7\u548c\u82a6\u4e01\u6bd4\u5176\u4ed6\u6210\u5206\u4f5c\u7528\u66f4\u5927\u3002<\/span><\/p>\n

\u7814\u7a76\u56e2\u961f\u8ba4\u4e3a\uff0c\u836f\u7269\u9776\u70b9\u901a\u8def\u7f51\u7edc\u836f\u7406\u5b66\u7ed3\u679c\u4e0e\u5b9e\u9a8c\u7ed3\u679c\u4e00\u81f4\uff0c\u8fd9\u8868\u660e\u8fde\u82b1\u6e05\u761f\u4e2d\u7684\u6d3b\u6027\u6210\u5206\u5177\u6709\u660e\u663e\u7684\u6297\u708e\u4f5c\u7528\uff0c\u53ef\u4ee5\u6fc0\u6d3bT\u7ec6\u80de\u80de\u8d28\u589e\u52a0T\u7ec6\u80de\u8868\u8fbe\uff0c\u51cf\u8f7b\u65b0\u51a0\u75c5\u6bd2\u75c7\u72b6\u3002<\/span><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u7814\u7a76\u56e2\u961f\u8ba4\u4e3a\uff0c\u6839\u636e\u7f51\u7edc\u836f\u7406\u5b66\u5206\u6790\uff0c\u8fde\u82b1\u6e05\u761f\u53ef\u901a\u8fc7\u5173\u952e\u5206\u5b50\u6fc0\u6d3b\u7684\u6297\u75c5\u6bd2\u3001\u6297\u708e\u7b49\u534f\u540c\u4f5c\u7528\u51cf\u8f7b\u65b0\u51a0\u80ba\u708e\u7684\u75c7\u72b6\u3002\u201c\u56e0\u6b64\uff0c\u8fde\u82b1\u6e05\u761f\u4e0d\u4ec5\u5177\u6709\u6297\u75c5\u6bd2\u4f5c\u7528\uff0c\u8fd8\u5177\u6709\u6297\u708e\u3001\u514d\u75ab\u7684\u4f5c\u7528\u673a\u5236\u3002\u8fd9\u4e5f\u7b26\u5408\u4e2d\u533b\u7684\u7279\u70b9\uff0c\u5373\u591a\u6210\u5206\u3001\u591a\u9776\u70b9\u3001\u591a\u9014\u5f84\u7684\u7efc\u5408\u6cbb\u7597\u590d\u6742\u75be\u75c5\u3002\u201d<\/span><\/p>\n

\u591a\u4f4d\u9662\u58eb\u7275\u5934\u8d1f\u8d23\u8fde\u82b1\u6e05\u761f\u6cbb\u7597\u65b0\u51a0\u80ba\u708e\u6216\u7591\u4f3c\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/span><\/p>\n

\u5b9e\u9645\u4e0a\uff0c\u8fde\u82b1\u6e05\u761f\u5728\u6b64\u6b21\u75ab\u60c5\u4e2d\u5173\u6ce8\u5ea6\u4e2d\u4e00\u76f4\u9887\u9ad8\u3002<\/span><\/p>\n

\u57283\u670823\u65e5\u4e0b\u5348\u56fd\u52a1\u9662\u65b0\u95fb\u529e\u516c\u5ba4\u4e8e\u6b66\u6c49\u4e3e\u884c\u7684\u65b0\u95fb\u53d1\u5e03\u4f1a\u4e0a\uff0c\u4e2d\u56fd\u5de5\u7a0b\u9662\u58eb\u3001\u5929\u6d25\u4e2d\u533b\u836f\u5927\u5b66\u6821\u957f\u5f20\u4f2f\u793c\u8868\u793a\uff0c\u4e34\u5e8a\u6570\u636e\u663e\u793a\uff0c\u91d1\u82b1\u6e05\u611f\u9897\u7c92\u548c\u8fde\u82b1\u6e05\u761f\u80f6\u56ca\u8fd9\u4e24\u79cd\u4e2d\u836f\u5bf9\u6cbb\u7597\u65b0\u51a0\u80ba\u708e\u5177\u6709\u786e\u5207\u7597\u6548\u3002<\/span><\/p>\n

\u5f20\u4f2f\u793c\u4ecb\u7ecd\uff0c\u8fde\u82b1\u6e05\u761f\u80f6\u56ca\u662f\u201c\u975e\u5178\u201d\u6d41\u884c\u671f\u95f4\u7814\u7a76\u51fa\u7684\u836f\u65b9\u3002\u75ab\u60c5\u671f\u95f4\uff0c\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u670d\u7528\u8fde\u82b1\u6e05\u761f\u80f6\u56ca\u7684\u60a3\u8005\uff0c\u5176\u4e3b\u8981\u4e34\u5e8a\u75c7\u72b6\u7684\u6d88\u5931\u7387\u3001\u4e34\u5e8a\u75c7\u72b6\u6301\u7eed\u7684\u65f6\u95f4\u7b49\u5747\u4f18\u4e8e\u5bf9\u7167\u7ec4\uff0c\u80ba\u90e8\u5f71\u50cf\u5b66\u7684\u597d\u8f6c\u8fbe\u5230\u4e8683.8%\uff0c\u4e34\u5e8a\u6cbb\u6108\u7387\u8fbe\u5230\u4e8678.9%\u3002\u6570\u636e\u8bc1\u660e\uff0c\u8fde\u82b1\u6e05\u6e29\u80f6\u56ca\u5bf9\u4e8e\u65b0\u51a0\u80ba\u708e\u5177\u6709\u6291\u5236\u4f5c\u7528\u3002<\/span><\/p>\n

\u5f20\u4f2f\u793c\u8fd8\u63d0\u5230\uff0c\u201c\u5efa\u8bae\u53d1\u70ed\u6bd4\u8f83\u8f7b\u3001\u5934\u75db\u4e25\u91cd\u7684\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u670d\u7528\u91d1\u82b1\u6e05\u611f\u9897\u7c92\uff1b\u53d1\u70ed\u91cd\u3001\u4fbf\u79d8\u7684\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u670d\u7528\u8fde\u82b1\u6e05\u761f\u80f6\u56ca\u3002\u201d<\/span><\/p>\n

\u6b64\u524d\u76842\u67086\u65e5\uff0c\u300a\u4e2d\u533b\u6742\u5fd7\u300b\u8fd8\u53d1\u8868\u4e86\u5f20\u4f2f\u793c\u56e2\u961f\u548c\u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u4e2d\u533b\u533b\u9662\u9662\u957f\u5218\u6e05\u6cc9\u56e2\u961f\u5408\u4f5c\u5b8c\u6210\u7684\u300a\u4e2d\u533b\u836f\u9632\u6cbb\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\u7684\u80ba\u708e\u5404\u5730\u8bca\u7597\u65b9\u6848\u7efc\u5408\u5206\u6790\u300b\uff08\u4e0b\u79f0\u201c\u300a\u8bca\u7597\u65b9\u6848\u7efc\u5408\u5206\u6790\u300b\u201d\uff09\uff0c\u8be5\u7814\u7a76\u9879\u76ee\u4e3a\u4e3a\u79d1\u6280\u90e8\u201c\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\u7684\u80ba\u708e\u75ab\u60c5\u79d1\u6280\u5e94\u5bf9\u201d\u5e94\u6025\u653b\u5173\u9879\u76ee\u3002<\/span><\/p>\n

\u5f20\u4f2f\u793c\u7b49\u4eba\u5168\u9762\u6536\u96c6\u3001\u6574\u7406\u5e76\u7cfb\u7edf\u5206\u6790\u4e86\u56fd\u5bb6\u53ca\u5404\u5730\u533a\u53d1\u5e03\u7684\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u611f\u67d3\u7684\u80ba\u708e\u8bca\u7597\u65b9\u6848\u3002\u622a\u81f3 2020\u5e74 2\u6708 3\u65e5\uff0c\u5168\u56fd\u5171\u6709 24\u4e2a\u5730\u533a\u53d1\u5e03\u4e86\u5404\u81ea\u7684\u4e2d\u533b\u836f\u5e72\u9884\u65b9\u6848\u3002\u56fd\u5bb6\u300a\u65b9\u6848\u300b\u65e0\u9884\u9632\u6027\u4e2d\u533b\u836f\u5e72\u9884\u63aa\u65bd\uff0c\u800c\u5730\u533a\u300a\u65b9\u6848\u300b\u4e2d6\u4e2a\u4e3a\u5355\u7eaf\u6cbb\u7597\u6027\u65b9\u6848\uff0c\u67093\u4e2a\u4e3a\u5355\u7eaf\u9884\u9632\u6027\u65b9\u6848\uff0c15\u4e2a\u4e3a\u9632\u6cbb\u6027\u65b9\u6848\u3002<\/span><\/p>\n

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\"u13586801361562465535fm173app49fJPEG\"<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\u300a\u8bca\u7597\u65b9\u6848\u7efc\u5408\u5206\u6790\u300b\u4e2d\u68b3\u7406\u4e86\u65b9\u836f\u63a8\u8350\u60c5\u51b5\uff0c\u6309\u7167\u5e94\u7528\u9891\u6b21\u6392\u5e8f\uff0c\u4e2d\u836f\u65b9\u5242\u4e2d\u9ebb\u674f\u77f3\u7518\u6c64\u9891\u6b21\u6700\u9ad8\u4e3a15\u6b21\uff1b\u5176\u6b21\u4e3a\u5ba3\u767d\u627f\u6c14\u6c64\u548c\u5347\u964d\u6563\uff1b\u4e2d\u6210\u836f\u4e2d\uff0c\u5b89\u5bab\u725b\u9ec4\u4e38\u9891\u6b21\u6700\u9ad8\u4e3a15\u6b21\uff0c\u5176\u6b21\u4e3a\u8840\u5fc5\u51c0\u6ce8\u5c04\u524214\u6b21\u548c\u8fde\u82b1\u6e05\u761f\u80f6\u56ca(\u9897\u7c92)12\u6b21\u3002<\/span><\/p>\n

3\u670820\u65e5\uff0c\u4e2d\u56fd\u5de5\u7a0b\u9662\u9662\u58eb\u949f\u5357\u5c71\u56e2\u961f\u4e5f\u5728\u300a\u836f\u7406\u5b66\u7814\u7a76\u300b(Pharmacological Research\uff0cIF 5.572)\u53d1\u5e03\u8bba\u6587\uff0c\u9898\u4e3a\u300a\u8fde\u82b1\u6e05\u6e29\u5bf9\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u5177\u6709\u6297\u75c5\u6bd2\u3001\u6297\u708e\u4f5c\u7528\u300b\u3002\u8fd9\u9879\u7814\u7a76\u91c7\u7528\u745e\u5fb7\u897f\u97e6\u4f5c\u4e3a\u9633\u6027\u5bf9\u7167\uff0c\u7814\u7a76\u8fde\u82b1\u6e05\u761f\u5728\u4f53\u5916\u5bf9\u4e8e\u65b0\u51a0\u75c5\u6bd2\u7684\u6291\u5236\u4f5c\u7528\u3002<\/span><\/p>\n

\u4ed6\u4eec\u7684\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u745e\u5fb7\u897f\u97e6\u7c7b\u4f3c\uff0c\u8fde\u82b1\u6e05\u761f\u4e5f\u53ef\u4ee5\u5728\u4f53\u5916\u6291\u5236\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u7684\u590d\u5236\uff0c\u8fde\u82b1\u6e05\u761f\u7684\u534a\u6291\u5236\u6d53\u5ea6\uff08IC50\uff09\u4e3a411.2\u03bcg\/ml\uff0c\u745e\u5fb7\u897f\u97e6\u7684IC50\u4e3a0.651\u03bcM\u3002\u8fde\u82b1\u6e05\u761f\u5904\u7406\u540e\u7ec6\u80de\u5185\u75c5\u6bd2\u9897\u7c92\u8868\u8fbe\u663e\u8457\u51cf\u5c11\uff0c\u5e76\u80fd\u53ef\u4ee5\u6291\u5236\u75c5\u6bd2\u611f\u67d3\u7ec6\u80de\u4ea7\u751f\u7684\u708e\u75c7\u56e0\u5b50\uff0cTNF-a\uff0cIL-6\uff0cMCP-1\u548cIP-10\u7684\u57fa\u56e0\u8868\u8fbe\u88ab\u8fde\u82b1\u6e05\u761f\u6291\u5236\uff0c\u4e14\u5177\u5242\u91cf\u4f9d\u8d56\u5173\u7cfb\u3002<\/span><\/p>\n

\u949f\u5357\u5c71\u7b49\u4eba\u603b\u7ed3\u9053\uff0c\u8fde\u82b1\u6e05\u761f\u663e\u8457\u6291\u5236SARS-COV-2\u590d\u5236\uff0c\u5f71\u54cd\u75c5\u6bd2\u5f62\u6001\u5e76\u5728\u4f53\u5916\u53d1\u6325\u6297\u708e\u6d3b\u6027\u3002\u8fd9\u8868\u660e\u8fde\u82b1\u6e05\u761f\u53ef\u4ee5\u62b5\u6297\u75c5\u6bd2\u653b\u51fb\uff0c\u6709\u671b\u6210\u4e3a\u63a7\u5236COVID-19\u75be\u75c5\u7684\u65b0\u7b56\u7565\u3002<\/span><\/p>\n

\n
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\"u40702383292906785fm173app49fJPG\"<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\u6b64\u5916\uff0c\u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u6ce8\u518c\u4e2d\u5fc3\u7684\u5b98\u65b9\u7f51\u7ad9\u663e\u793a\uff0c\u76ee\u524d\u5df2\u6709\u4e24\u9879\u5173\u4e8e\u8fde\u82b1\u6e05\u761f\u6cbb\u7597\u65b0\u51a0\u80ba\u708e\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5747\u4e8e2\u67081\u65e5\u6ce8\u518c\uff0c\u72b6\u6001\u4e3a\u9884\u6ce8\u518c\u3002<\/span><\/p>\n

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