{"id":27847,"date":"2024-03-29T15:59:24","date_gmt":"2024-03-29T19:59:24","guid":{"rendered":"https:\/\/septdays.com\/?p=27847"},"modified":"2024-03-29T15:59:24","modified_gmt":"2024-03-29T19:59:24","slug":"%e7%bb%88%e7%bb%93%e8%a1%b0%e8%80%81-%e5%ba%a6%e8%bf%87%e6%b2%a1%e6%9c%89%e7%96%be%e7%97%85%e6%88%96%e5%a4%b1%e8%83%bd%e7%9a%84%e4%ba%ba%e7%94%9f-%e5%93%88%e4%bd%9b%e5%a4%a7%e5%ad%a6","status":"publish","type":"post","link":"https:\/\/septdays.com\/?p=27847","title":{"rendered":"\u7ec8\u7ed3\u8870\u8001 \u5ea6\u8fc7\u6ca1\u6709\u75be\u75c5\u6216\u5931\u80fd\u7684\u4eba\u751f\u2014\u2014\u54c8\u4f5b\u5927\u5b66\u6559\u6388David Sinclair\u535a\u58eb\u5728\u51ef\u4e3d\u751f\u6d3b\u5cf0\u4f1a\u4e0a\u7684\u6f14\u8bb2"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p><strong><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"534\" data-attachment-id=\"27848\" data-permalink=\"https:\/\/septdays.com\/?attachment_id=27848#main\" 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Kenyon\u7684\u7814\u7a76\u53d1\u73b0\uff0cDaf-2\u57fa\u56e0\u88ab\u7834\u574f\u4e4b\u540e\u4e0d\u4ec5\u8ba9\u7ebf\u866b\u7684\u5bff\u547d\u589e\u52a0\u4e86\u4e00\u500d\uff0c\u8fd8\u771f\u6b63\u505a\u5230\u4e86\u5ef6\u7f13\u8870\u8001\uff0c\u5373\u5230\u4e86\u6b63\u5e38\u7ebf\u866b\u8001\u5e74\u671f\u7684\u7a81\u53d8\u7ebf\u866b\u8fd8\u5f88\u5e74\u8f7b\u3001\u6d3b\u8dc3\uff0c\u800c\u4e14\u6709\u7e41\u6b96\u80fd\u529b\u3002\u8fd9\u9879\u7814\u7a76\u4f7f\u5f97Daf-2\u53ca\u5176\u6240\u5728\u7684\u4ee3\u8c22\u901a\u8def\u6210\u4e3a\u6700\u65e9\u53d1\u73b0\u4e0e\u957f\u5bff\u76f8\u5173\u7684\u57fa\u56e0\u4e4b\u4e00\u3002<\/p>\n<p>\u5e74\u4ec524\u5c81\u5c31\u6210\u4e3aGuarente\u5b9e\u9a8c\u5ba4\u535a\u58eb\u540e\u7684\u8f9b\u514b\u83b1\u5f00\u59cb\u7814\u7a76\u9175\u6bcd\u7684\u8001\u5316\uff0c\u4ed6\u5e38\u5e38\u7b2c\u4e00\u4e2a\u8fdb\u5b9e\u9a8c\u5ba4\uff0c\u4e3a\u4e86\u8d76\u6700\u540e\u4e00\u73ed\u591c\u8f66\u624d\u79bb\u5f00\uff0c\u6bcf\u5929\u90fd\u6597\u5fd7\u6ee1\u6ee1\uff0c\u4e0d\u77e5\u75b2\u5026\u3002\u5f53\u65f6\u7684\u8001\u9f84\u5316\u7814\u7a76\u8fd8\u5904\u4e8e\u8d77\u6b65\u9636\u6bb5\uff0c\u7b97\u662f\u4e00\u95e8\u8fb9\u7f18\u79d1\u5b66\uff0c\u4f46\u8f9b\u514b\u83b1\u51b3\u5fc3\u63a8\u52a8\u5176\u6b63\u7edf\u5316\u5e76\u53d6\u5f97\u4e86\u7a81\u7834\u6027\u7684\u53d1\u73b0\uff0c\u9996\u6b21\u89e3\u91ca\u4e86\u9175\u6bcd\u8870\u8001\u7684\u673a\u5236\u3002\u5176\u5b9e\u65e9\u57281991\u5e74\uff0c\u74dc\u4f26\u7279\u5c1d\u8bd5\u5728\u5355\u7ec6\u80de\u6709\u673a\u4f53\u9175\u6bcd\u4e2d\u5bfb\u627e\u6709\u53ef\u80fd\u5b58\u5728\u7684\u957f\u5bff\u57fa\u56e0\u65f6\uff0c\u4e00\u79cd\u540d\u4e3aSir-2\u7684\u57fa\u56e0\u5c31\u51fa\u4eba\u610f\u6599\u5730\u5d2d\u9732\u4e86\u5934\u89d2\uff0c\u5728\u5c0f\u9f20\u548c\u4eba\u7c7b\u4e2d\u7684\u5bf9\u5e94\u57fa\u56e0\u88ab\u79f0\u4e3a Sirtuin-1\uff0c\u8fd9\u4e3a\u540e\u7eed\u7814\u7a76\u4eba\u7c7b\u8870\u8001\u8fc7\u7a0b\u5960\u5b9a\u4e86\u57fa\u7840\u3002<\/p>\n<p>1999\u5e74\uff0c\u5b8c\u6210\u535a\u58eb\u5b66\u4e1a\u540e\u7684\u8f9b\u514b\u83b1\u53d7\u8058\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u7684\u9057\u4f20\u5b66\u52a9\u7406\u6559\u6388\u3002\u7ee7\u7eed\u8fdb\u884c\u5728Guarente\u5b9e\u9a8c\u5ba4\u7684\u7814\u7a76\u2014\u2014\u5173\u4e8eSirtuins\u86cb\u767d\u7684\u53d1\u73b0\u548c\u53d1\u5c55\u3002Sirtuins\u86cb\u767d\u901a\u5e38\u5904\u4e8e\u4f11\u7720\u72b6\u6001\uff0c\u4f46\u4f1a\u88ab\u538b\u529b\uff08\u5982\u9650\u5236\u5361\u8def\u91cc\uff09\u6fc0\u6d3b\uff0c\u5ef6\u957f\u9175\u6bcd\u7684\u5bff\u547d\u3002\u8f9b\u514b\u83b1\u51b3\u5fc3\u627e\u5230\u4e00\u79cd\u7269\u8d28\uff0c\u53ef\u4ee5\u6a21\u4eff\u9175\u6bcd\u88ab\u9650\u5236\u70ed\u91cf\u540e\u7684\u6548\u679c\u3002\u4ed6\u7b5b\u9009\u4e86\u5927\u7ea620,000\u79cd\u5316\u5408\u7269\u6765\u8fdb\u884c\u9175\u6bcd\u5b9e\u9a8c\uff0c\u76f4\u5230\u6709\u4e00\u5929\uff0c\u4e00\u540d\u56e2\u961f\u4f19\u4f34\u6253\u6765\u7535\u8bdd\u79f0\u4e00\u79cd\u4ece\u7ea2\u9152\u4e2d\u53d1\u73b0\u7684\u5206\u5b50\u2014\u2014\u767d\u85dc\u82a6\u9187\u5177\u6709\u79ef\u6781\u4f5c\u7528\u3002\u4e8e\u662f\u4ed6\u5f00\u59cb\u7740\u624b\u7528\u4e0d\u540c\u7684\u7269\u8d28\u5582\u98df\u9175\u6bcd\uff0c\u7ed3\u679c\u53d1\u73b0\u5582\u98df\u767d\u85dc\u82a6\u9187\u7684\u9175\u6bcd\u591a\u6d3b\u4e8650%\uff0c\u8fd9\u4e00\u53d1\u73b0\u662f\u8f9b\u514b\u83b1\u5b66\u672f\u751f\u6daf\u7684\u4e00\u5ea7\u91cc\u7a0b\u7891\u3002<\/p>\n<p>2003\u5e749\u6708\uff0c\u8f9b\u514b\u83b1\u4e0e\u56e2\u961f\u4f19\u4f34Howitz\u7b49\u4eba\u5728\u9876\u5c16\u6742\u5fd7\u300a\u81ea\u7136\u300b\uff08Nature\uff09\u53d1\u8868\u4e86\u4e00\u7bc7\u5f15\u53d1\u9ad8\u5ea6\u5173\u6ce8\u7684\u8bba\u6587\uff0c\u62a5\u544a\u79f0\u767d\u85dc\u82a6\u9187\u7b49\u591a\u915a\u80fd\u6fc0\u6d3b\u4eba\u7c7b\u7684Sirtuins 1\uff0c\u4ece\u800c\u5ef6\u957f\u7ec6\u80de\u7684\u5bff\u547d\u3002\u8f9b\u514b\u83b1\u5173\u4e8e\u767d\u85dc\u82a6\u9187\u7684\u8a00\u8bba\u66f4\u662f\u95fb\u540d\uff0c\u5982\u201c\u767d\u85dc\u82a6\u9187\u662f\u80fd\u627e\u5230\u7684\u4e00\u79cd\u795e\u5947\u5206\u5b50\uff0c\u4e00\u767e\u5e74\u540e\uff0c\u4eba\u4eec\u53ef\u80fd\u6bcf\u5929\u90fd\u670d\u7528\u8fd9\u4e9b\u5206\u5b50\u6765\u9884\u9632\u5fc3\u810f\u75c5\u3001\u4e2d\u98ce\u3001\u8111\u90e8\u75be\u75c5\u548c\u764c\u75c7\u3002\u201d2004\u5e74\uff0c\u8f9b\u514b\u83b1\u5c14\u6536\u5230\u6148\u5584\u5bb6Paul F. Glenn\u7684500\u4e07\u7f8e\u5143\u6350\u6b3e\uff0c\u6210\u7acb\u4e86Paul F. Glenn\u8870\u8001\u751f\u7269\u673a\u5236\u5b9e\u9a8c\u5ba4\uff0c\u4ed6\u4f5c\u4e3a\u521b\u59cb\u8463\u4e8b\u5e76\u6267\u638c\u8fd9\u4e2a\u5b9e\u9a8c\u5ba4\u81f3\u4eca\u3002<\/p>\n<p>\u540c\u4e00\u5e74\uff0c\u5728\u751f\u7269\u6280\u672f\u8fde\u73af\u521b\u4e1a\u5bb6Christoph Westphal\u7684\u8d44\u52a9\u4e0b\uff0c\u8f9b\u514b\u83b1\u521b\u529e\u4e86\u4e00\u5bb6\u540d\u4e3aSirtris Pharmaceuticals\u7684\u516c\u53f8\uff0c\u4ee5\u767d\u85dc\u82a6\u9187\u4e3a\u7075\u611f\u5f00\u53d1\u4e34\u5e8a\u836f\u7269\u3002\u5f53\u65f6\uff0c\u51e0\u4e4e\u6ca1\u6709\u6297\u8870\u8001\u533b\u5b66\u9886\u57df\u7684\u79d1\u5b66\u5bb6\u521b\u529e\u516c\u53f8\uff0c\u8f9b\u514b\u83b1\u5f00\u521b\u4e86\u5b66\u672f\u548c\u5546\u4e1a\u76f8\u7ed3\u5408\u7684\u5148\u6cb3\uff0c\u540e\u6765\u8fd9\u5bb6\u516c\u53f8\u57282007\u5e74\u4e0a\u5e02\uff0c\u57282008\u5e74\u4ee57.2\u4ebf\u7f8e\u5143\u7684\u4ef7\u683c\u88abGlaxoSmithKline\u6536\u8d2d\uff0c\u6210\u4e3a\u5176\u5b50\u516c\u53f8\u3002\u4e0d\u8fc7\u8fd9\u4e2a\u65f6\u671f\u6709\u5173\u767d\u85dc\u82a6\u9187\u7684\u7814\u7a76\u6210\u679c\u8fd8\u4e3b\u8981\u505c\u7559\u5728\u79d1\u5b66\u9886\u57df\uff0c\u5e76\u6ca1\u6709\u5728\u516c\u4f17\u5c42\u9762\u4ea7\u751f\u7279\u522b\u5927\u7684\u5f71\u54cd\uff0c\u4f46\u8fd9\u4e00\u5207\u57282006\u5e74\u53d1\u751f\u4e86\u5f7b\u5e95\u6539\u53d8\u3002\u8f9b\u514b\u83b1\u548cJoseph Baur\u8054\u5408\u53d1\u8868\u5728\u300a\u81ea\u7136\u300b\u4e0a\u7684\u8bba\u6587\u7684\u300a\u767d\u85dc\u82a6\u9187\u7684\u6f5c\u5728\u6cbb\u7597\uff1a\u4f53\u5185\u8bc1\u636e\u300b\uff08Therapeutic potential of resveratrol: the in vivo evidence\uff09\u5f15\u53d1\u8f70\u52a8\uff0c\u5f15\u53d1\u6570\u5341\u5bb6\u5a92\u4f53\u7684\u5173\u6ce8\uff0c\u5e76\u767b\u4e0a\u300a\u7ebd\u7ea6\u65f6\u62a5\u300b\u5934\u7248\u3002\u5a92\u4f53\u8fde\u7bc7\u7d2f\u724d\u7684\u62a5\u9053\uff0c\u52a0\u4e0a\u8f9b\u514b\u83b1\u5728\u955c\u5934\u9762\u524d\u5c55\u73b0\u51fa\u7684\u8ff7\u4eba\u98ce\u91c7\u8ba9\u4ed6\u4e00\u591c\u6210\u540d\uff0c\u4ece\u4e00\u540d\u5728\u5b9e\u9a8c\u5ba4\u91cc\u57cb\u5934\u82e6\u5e72\u7684\u79d1\u5b66\u5bb6\uff0c\u53d8\u6210\u4e86\u4e00\u4e2a\u5728\u8857\u4e0a\u968f\u65f6\u80fd\u88ab\u8ba4\u51fa\u7684\u540d\u4eba\uff0c\u6210\u4e86\u957f\u5bff\u9886\u57df\u7684\u5b97\u5e08\uff0c\u88ab\u8a89\u4e3a\u201c\u6297\u8870\u6765\u4e4b\u7236\u3002\u201d<\/p>\n<p>\u767d\u85dc\u82a6\u9187\u8ba9\u8f9b\u514b\u83b1\u540d\u5229\u53cc\u6536\uff0c\u4e5f\u7ed9\u4ed6\u7684\u7814\u7a76\u5e26\u6765\u8d28\u7591\u3002\u4ed6Guarente\u5b9e\u9a8c\u5ba4\u7684\u4e24\u4f4d\u524d\u540c\u4e8b\u53d1\u8868\u4e86\u4e00\u7bc7\u8bba\u6587\uff0c\u79f0\u65e0\u6cd5\u91cd\u590d\u767d\u85dc\u82a6\u9187\u5b9e\u9a8c\u7ed3\u679c\uff0c\u8f9b\u514b\u83b1\u7684\u7ed3\u8bba\u53ef\u80fd\u662f\u9519\u8bef\u7684\u3002\u4e16\u754c\u6700\u5927\u7684\u5236\u836f\u516c\u53f8\u8f89\u745e\u7684\u79d1\u5b66\u5bb6\u4e0d\u4ec5\u58f0\u79f0\u8f9b\u514b\u83b1\u5728\u767d\u85dc\u82a6\u9187\u4e0a\u7684\u7814\u7a76\u7ed3\u8bba\u53ef\u80fd\u662f\u9519\u8bef\u7684\uff0c\u8fd8\u79f0\u4ed6\u5173\u4e8eSirtuins\u57fa\u56e0\u7684\u6574\u4e2a\u7406\u8bba\u53ef\u80fd\u90fd\u662f\u9519\u8bef\u7684\u3002\u6765\u81ea\u5404\u4e2a\u65b9\u9762\u7684\u8d28\u7591\u4e00\u5ea6\u8ba9\u4ed6\u7684\u5b9e\u9a8c\u5ba4\u53ea\u5269\u4e0b4\u4eba\uff0c\u4f46\u575a\u6301\u4eba\u751f\u6c38\u4e0d\u8a00\u8d25\u4fe1\u6761\u7684\u8f9b\u514b\u83b1\u53ea\u8eba\u5728\u5e8a\u4e0a\u6d88\u6c89\u4e86\u4e00\u4e2a\u661f\u671f\u540e\uff0c\u5c31\u56de\u5230\u5b9e\u9a8c\u5ba4\u53bb\u8bc1\u660e\u53cd\u5bf9\u8005\u662f\u9519\u8bef\u7684\u3002\u6700\u7ec8\u4ed6\u57282013\u5e74\u53d1\u8868\u7684\u4e00\u7bc7\u8bba\u6587\u4e3a\u8fd9\u573a\u4e89\u7aef\u753b\u4e0a\u4e86\u53e5\u53f7\uff1a\u8bba\u6587\u8bc1\u5b9e\u901a\u8fc7\u57fa\u56e0\u5de5\u7a0b\u6539\u53d8Sirtuins\u4e0a\u7684\u4e00\u4e2a\u6c28\u57fa\u9178\u65f6\uff0c\u767d\u85dc\u82a6\u9187\u5bf9\u7ec6\u80de\u6ca1\u6709\u4f5c\u7528\uff1b\u800c\u5728\u8868\u8fbe\u5b8c\u6574Sirtuins\u7684\u5bf9\u7167\u7ec6\u80de\u4e2d\uff0c\u767d\u85dc\u82a6\u9187\u786e\u6709\u4f5c\u7528\uff0c\u4e5f\u5c31\u662f\u8bf4\u767d\u85dc\u82a6\u9187\u6fc0\u6d3bSirtuins\u7684\u8bf4\u6cd5\u662f\u6b63\u786e\u7684<\/p>\n<p>\u5728\u63a2\u7d22\u6297\u8870\u8001\u9886\u57df\u594b\u52c7\u524d\u884c\u7684\u8f9b\u514b\u83b1\u53c8\u57282013\u5e7412\u6708\u5728\u9876\u7ea7\u520a\u7269\u300a\u7ec6\u80de\u300b\uff08Cell\uff09\u6742\u5fd7\u4e0a\u53d1\u6587\u79f0\uff0c\u4e00\u79cd\u5e7f\u6cdb\u5b58\u5728\u4e8e\u65e5\u5e38\u98df\u7269\u4e2d\u7684\u540d\u4e3a NMN \uff08Nicotinamide mononucleotide \uff0c\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178\uff0c\u4e00\u79cd\u7ef4\u751f\u7d20B3\u7684\u884d\u751f\u7269\uff09\u7684\u7269\u8d28\u53ef\u4ee5\u8f6c\u5316\u4e3a\u4f53\u5185\u7684 NAD+\uff08\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178\uff09\uff0c\u4ece\u800c\u8c03\u8282\u6240\u6709\u7ec6\u80de\u7684\u7ebf\u7c92\u4f53\u6216\u80fd\u91cf\u4ee3\u8c22\uff0c\u8ba9\u4eba\u4f53\u7ef4\u6301\u5e74\u8f7b\u6001\u30022017 \u5e74 3 \u6708\u7684\u300a\u79d1\u5b66\u300b\uff08Science\uff09\u4e0a\uff0c\u4ed6\u53d1\u8868\u7684\u6587\u7ae0\u63d0\u51fa\u4e86\u4e00\u79cd\u9006\u8f6c\u8870\u8001\u7684\u7b80\u6d01\u529e\u6cd5\uff1a\u901a\u8fc7\u8865\u5145NMN\u6765\u589e\u52a0 NAD+\u3002\u56e0\u4e3aNAD+\u662f\u5927\u5206\u5b50\uff0c\u4eba\u4f53\u65e0\u6cd5\u76f4\u63a5\u5438\u6536\uff0c\u4ece\u53d1\u73b0NAD+\u7684100\u591a\u5e74\u91cc\uff0c\u7814\u7a76\u4eba\u5458\u4e00\u76f4\u5728\u627e\u8865\u5145NAD+\u7684\u529e\u6cd5\uff0c\u59cb\u7ec8\u6ca1\u6709\u627e\u5230\uff0c\u76f4\u5230NMN\u7684\u53d1\u73b0\u3002\u57282019\u5e74\u51fa\u7248\u7684\u7545\u9500\u4e66\u300a\u957f\u5bff\u00b7\u5f53\u4eba\u7c7b\u4e0d\u518d\u8870\u8001\u300b\u4e2d\uff0c\u8f9b\u514b\u83b1\u5411\u516c\u4f17\u4ecb\u7ecd\u4ed6\u7684\u7814\u7a76\u6210\u679c\u4ee5\u53ca\u5982\u4f55\u5f00\u53d1\u6f5c\u529b\uff0c\u5ef6\u957f\u751f\u547d\u3002<\/p>\n<p>\u8f9b\u514b\u83b1\u4e0d\u4ec5\u662f\u4e00\u4f4d\u7814\u7a76\u6210\u679c\u5353\u8457\u7684\u79d1\u5b66\u5bb6\uff0c\u8fd8\u662f\u4e00\u4f4d\u6d3b\u8dc3\u7684\u79d1\u666e\u4f5c\u5bb6\u548c\u516c\u5171\u6f14\u8bb2\u8005\uff0c\u4ed6\u7ecf\u5e38\u548c\u5408\u4f5c\u4f19\u4f34\u3001\u8425\u517b\u5b66\u8005\u3001\u7814\u7a76\u957f\u5bff\u5065\u5eb7\u7684Serena 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To\uff09\u7684\u4f5c\u8005\u3001\u54c8\u4f5b\u5927\u5b66\u9057\u4f20\u5b66\u6559\u6388\u5927\u536b\u00b7\u8f9b\u514b\u83b1\uff08David Sinclair\uff09\u535a\u58eb\u5728\u5cf0\u4f1a\u4e0a\u89c1\u9762\uff0c\u5c31\u751f\u547d\u79d1\u5b66\u53d1\u5c55\u8d8b\u52bf\u8fdb\u884c\u4e86\u63a2\u8ba8\u3002\u8f9b\u514b\u83b1\u535a\u58eb\u6307\u51fa\u4eba\u7684\u8870\u8001\u5e76\u4e0d\u662f\u4e0d\u53ef\u6297\u7684\u81ea\u7136\u89c4\u5f8b\uff0c\u800c\u662f\u4e00\u79cd\u53ef\u9632\u53ef\u63a7\u7684\u75be\u75c5\u3002\u5728\u4ed6\u770b\u6765\uff0c\u8870\u8001\u5c31\u50cfCD\u4e0a\u53ef\u4ee5\u64e6\u6389\u7684\u5212\u75d5\uff0c\u6216\u8005\u7cfb\u7edf\u91cc\u635f\u574f\u7684\u8f6f\u4ef6\uff0c\u53ea\u9700\u91cd\u65b0\u5b89\u88c5\u5373\u53ef\u5b9e\u73b0\u9006\u8f6c\uff0c\u6b63\u5982\u4ed6\u57282019\u5e74\u51fa\u7248\u7684\u8457\u4f5c\u300aLifespan\u300b\u4e2d\u6240\u8bf4\u7684\u90a3\u6837\u3002 \u8f9b\u514b\u83b1\u5176\u4eba \u8f9b\u514b\u83b1\u4e8e1969\u5e746\u670826\u65e5\u51fa\u751f\u5728\u6fb3\u5927\u5229\u4e9a\u65b0\u5357\u5a01\u5c14\u58eb\u5dde\u7684\u5723\u827e\u592b\u65af\uff08St Ives\uff09\u3002\u7ed9\u4ed6\u4e00\u751f\u5e26\u6765\u91cd\u8981\u5f71\u54cd\u7684\u7956\u6bcd\u57281956\u5e74\u5308\u7259\u5229\u7206\u53d1\u9769\u547d\u88ab\u9547\u538b\u540e\u8f97\u8f6c\u9003\u4ea1\u5230\u6fb3\u5927\u5229\u4e9a\uff0c\u4ed6\u7684\u7236\u4eb2\u5c06\u539f\u6765\u7684\u59d3\u6c0fSzigeti\u6539\u6210\u4e86Sinclair\u3002\u8f9b\u514b\u83b1\u7684\u7236\u6bcd\u90fd\u662f\u751f\u7269\u5316\u5b66\u5bb6\uff0c\u5de5\u4f5c\u5f88\u5fd9\u3002\u8f9b\u514b\u83b1\u5927\u90e8\u5206\u7684\u7ae5\u5e74\u65f6\u5149\u90fd\u662f\u548c\u7956\u6bcd\u5728\u6089\u5c3c\u90ca\u533a\u68ee\u6797\u8fb9\u7684\u4e00\u680b\u623f\u5c4b\u91cc\u4e00\u8d77\u5ea6\u8fc7\u7684\uff0c\u800c\u4ed6\u7684\u7956\u6bcd\u662f\u4e00\u4e2a\u559c\u6b22\u73a9\u4e50\u3001\u81ea\u7531\u5954\u653e\u7684\u4eba\uff0c\u5e0c\u671b\u4eba\u6c38\u8fdc\u957f\u4e0d\u5927\u3002\u8f9b\u514b\u83b1\u4ece\u5c0f\u5c31\u5bf9\u672a\u77e5\u7684\u4e8b\u60c5\u5145\u6ee1\u597d\u5947\uff0c\u559c\u6b22\u62c6\u4e1c\u897f\u53bb\u4e86\u89e3\u6765\u9f99\u53bb\u8109\u3002\u5b66\u4e60\u6210\u7ee9\u4f18\u5f02\u7684\u8f9b\u514b\u83b1\u5728\u8fdb\u5165\u65b0\u5357\u5a01\u5c14\u58eb\u5927\u5b66\u5b66\u4e60\u751f\u7269\u5316\u5b66\u65f6\uff0c\u5c31\u8ba4\u4e3a\u603b\u6709\u4e00\u5929\u79d1\u5b66\u4f1a\u5b9e\u73b0\u4ed6\u7956\u6bcd\u7684\u60f3\u6cd5\uff0c\u4eba\u4eec\u5c06\u6c38\u8fdc\u4fdd\u6301\u5e74\u8f7b\u3002\u5728\u8bfb\u535a\u58eb\u65f6\u671f\u76841993\u5e74\uff0c\u8f9b\u514b\u83b1\u9047\u5230\u4e86\u5230\u6fb3\u5927\u5229\u4e9a\u8fdb\u884c\u5b66\u672f\u4ea4\u6d41\u7684\u9ebb\u7701\u7406\u5de5\u5b66\u9662\uff08MIT\uff09\u7814\u7a76\u4e0e\u8870\u8001\u8c03\u8282\u6709\u5173\u7684\u57fa\u56e0\u5b66\u6559\u6388\u74dc\u4f26\u7279\uff08Leonard P. Guarente\uff09\uff0c\u8fd9\u6b21\u4f1a\u9762\u6fc0\u53d1\u4e86\u8f9b\u514b\u83b1\u7533\u8bf7\u5176\u7814\u7a76\u751f\u5e76\u83b7\u5f97Guarente\u5b9e\u9a8c\u5ba4\u535a\u58eb\u540e\u804c\u4f4d\u7684\u613f\u610f\u3002\u5c31\u5728\u540c\u4e00\u5e74\uff0c\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\u7684 Cynthia Kenyon \u5b9e\u9a8c\u5ba4\u53d1\u73b0\u79c0\u4e3d\u9690\u6746\u7ebf\u866b\uff08Caenorhabditis elegans\uff09\u4f53\u5185Daf-2\u5355\u4e2a\u57fa\u56e0\u7a81\u53d8\u5c31\u53ef\u4ee5\u4f7f\u8fd9\u79cd\u7ebf\u866b\u7684\u5bff\u547d\u5ef6\u957f\u4e00\u500d\uff0c\u7531\u6b64\u62c9\u5f00\u4e86\u8870\u8001\u5206\u5b50\u8c03\u63a7\u673a\u7406\u7814\u7a76\u7684\u5e8f\u5e55\u3002\u79c0\u4e3d\u9690\u6746\u7ebf\u866b\u662f\u4e00\u79cd\u957f\u5ea6\u4ec5\u67091.5\u5398\u7c73\u3001\u5bff\u547d\u5e73\u57472-3\u5468\u7684\u7ebf\u866b\uff0c\u56e0\u5176\u5bff\u547d\u8f83\u77ed\uff0c\u5e38\u88ab\u7528\u6765\u7814\u7a76\u5982\u4f55\u5ef6\u957f\u5bff\u547d\u3002Cynthia Kenyon\u7684\u7814\u7a76\u53d1\u73b0\uff0cDaf-2\u57fa\u56e0\u88ab\u7834\u574f\u4e4b\u540e\u4e0d\u4ec5\u8ba9\u7ebf\u866b\u7684\u5bff\u547d\u589e\u52a0\u4e86\u4e00\u500d\uff0c\u8fd8\u771f\u6b63\u505a\u5230\u4e86\u5ef6\u7f13\u8870\u8001\uff0c\u5373\u5230\u4e86\u6b63\u5e38\u7ebf\u866b\u8001\u5e74\u671f\u7684\u7a81\u53d8\u7ebf\u866b\u8fd8\u5f88\u5e74\u8f7b\u3001\u6d3b\u8dc3\uff0c\u800c\u4e14\u6709\u7e41\u6b96\u80fd\u529b\u3002\u8fd9\u9879\u7814\u7a76\u4f7f\u5f97Daf-2\u53ca\u5176\u6240\u5728\u7684\u4ee3\u8c22\u901a\u8def\u6210\u4e3a\u6700\u65e9\u53d1\u73b0\u4e0e\u957f\u5bff\u76f8\u5173\u7684\u57fa\u56e0\u4e4b\u4e00\u3002 \u5e74\u4ec524\u5c81\u5c31\u6210\u4e3aGuarente\u5b9e\u9a8c\u5ba4\u535a\u58eb\u540e\u7684\u8f9b\u514b\u83b1\u5f00\u59cb\u7814\u7a76\u9175\u6bcd\u7684\u8001\u5316\uff0c\u4ed6\u5e38\u5e38\u7b2c\u4e00\u4e2a\u8fdb\u5b9e\u9a8c\u5ba4\uff0c\u4e3a\u4e86\u8d76\u6700\u540e\u4e00\u73ed\u591c\u8f66\u624d\u79bb\u5f00\uff0c\u6bcf\u5929\u90fd\u6597\u5fd7\u6ee1\u6ee1\uff0c\u4e0d\u77e5\u75b2\u5026\u3002\u5f53\u65f6\u7684\u8001\u9f84\u5316\u7814\u7a76\u8fd8\u5904\u4e8e\u8d77\u6b65\u9636\u6bb5\uff0c\u7b97\u662f\u4e00\u95e8\u8fb9\u7f18\u79d1\u5b66\uff0c\u4f46\u8f9b\u514b\u83b1\u51b3\u5fc3\u63a8\u52a8\u5176\u6b63\u7edf\u5316\u5e76\u53d6\u5f97\u4e86\u7a81\u7834\u6027\u7684\u53d1\u73b0\uff0c\u9996\u6b21\u89e3\u91ca\u4e86\u9175\u6bcd\u8870\u8001\u7684\u673a\u5236\u3002\u5176\u5b9e\u65e9\u57281991\u5e74\uff0c\u74dc\u4f26\u7279\u5c1d\u8bd5\u5728\u5355\u7ec6\u80de\u6709\u673a\u4f53\u9175\u6bcd\u4e2d\u5bfb\u627e\u6709\u53ef\u80fd\u5b58\u5728\u7684\u957f\u5bff\u57fa\u56e0\u65f6\uff0c\u4e00\u79cd\u540d\u4e3aSir-2\u7684\u57fa\u56e0\u5c31\u51fa\u4eba\u610f\u6599\u5730\u5d2d\u9732\u4e86\u5934\u89d2\uff0c\u5728\u5c0f\u9f20\u548c\u4eba\u7c7b\u4e2d\u7684\u5bf9\u5e94\u57fa\u56e0\u88ab\u79f0\u4e3a Sirtuin-1\uff0c\u8fd9\u4e3a\u540e\u7eed\u7814\u7a76\u4eba\u7c7b\u8870\u8001\u8fc7\u7a0b\u5960\u5b9a\u4e86\u57fa\u7840\u3002 1999\u5e74\uff0c\u5b8c\u6210\u535a\u58eb\u5b66\u4e1a\u540e\u7684\u8f9b\u514b\u83b1\u53d7\u8058\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u7684\u9057\u4f20\u5b66\u52a9\u7406\u6559\u6388\u3002\u7ee7\u7eed\u8fdb\u884c\u5728Guarente\u5b9e\u9a8c\u5ba4\u7684\u7814\u7a76\u2014\u2014\u5173\u4e8eSirtuins\u86cb\u767d\u7684\u53d1\u73b0\u548c\u53d1\u5c55\u3002Sirtuins\u86cb\u767d\u901a\u5e38\u5904\u4e8e\u4f11\u7720\u72b6\u6001\uff0c\u4f46\u4f1a\u88ab\u538b\u529b\uff08\u5982\u9650\u5236\u5361\u8def\u91cc\uff09\u6fc0\u6d3b\uff0c\u5ef6\u957f\u9175\u6bcd\u7684\u5bff\u547d\u3002\u8f9b\u514b\u83b1\u51b3\u5fc3\u627e\u5230\u4e00\u79cd\u7269\u8d28\uff0c\u53ef\u4ee5\u6a21\u4eff\u9175\u6bcd\u88ab\u9650\u5236\u70ed\u91cf\u540e\u7684\u6548\u679c\u3002\u4ed6\u7b5b\u9009\u4e86\u5927\u7ea620,000\u79cd\u5316\u5408\u7269\u6765\u8fdb\u884c\u9175\u6bcd\u5b9e\u9a8c\uff0c\u76f4\u5230\u6709\u4e00\u5929\uff0c\u4e00\u540d\u56e2\u961f\u4f19\u4f34\u6253\u6765\u7535\u8bdd\u79f0\u4e00\u79cd\u4ece\u7ea2\u9152\u4e2d\u53d1\u73b0\u7684\u5206\u5b50\u2014\u2014\u767d\u85dc\u82a6\u9187\u5177\u6709\u79ef\u6781\u4f5c\u7528\u3002\u4e8e\u662f\u4ed6\u5f00\u59cb\u7740\u624b\u7528\u4e0d\u540c\u7684\u7269\u8d28\u5582\u98df\u9175\u6bcd\uff0c\u7ed3\u679c\u53d1\u73b0\u5582\u98df\u767d\u85dc\u82a6\u9187\u7684\u9175\u6bcd\u591a\u6d3b\u4e8650%\uff0c\u8fd9\u4e00\u53d1\u73b0\u662f\u8f9b\u514b\u83b1\u5b66\u672f\u751f\u6daf\u7684\u4e00\u5ea7\u91cc\u7a0b\u7891\u3002 2003\u5e749\u6708\uff0c\u8f9b\u514b\u83b1\u4e0e\u56e2\u961f\u4f19\u4f34Howitz\u7b49\u4eba\u5728\u9876\u5c16\u6742\u5fd7\u300a\u81ea\u7136\u300b\uff08Nature\uff09\u53d1\u8868\u4e86\u4e00\u7bc7\u5f15\u53d1\u9ad8\u5ea6\u5173\u6ce8\u7684\u8bba\u6587\uff0c\u62a5\u544a\u79f0\u767d\u85dc\u82a6\u9187\u7b49\u591a\u915a\u80fd\u6fc0\u6d3b\u4eba\u7c7b\u7684Sirtuins 1\uff0c\u4ece\u800c\u5ef6\u957f\u7ec6\u80de\u7684\u5bff\u547d\u3002\u8f9b\u514b\u83b1\u5173\u4e8e\u767d\u85dc\u82a6\u9187\u7684\u8a00\u8bba\u66f4\u662f\u95fb\u540d\uff0c\u5982\u201c\u767d\u85dc\u82a6\u9187\u662f\u80fd\u627e\u5230\u7684\u4e00\u79cd\u795e\u5947\u5206\u5b50\uff0c\u4e00\u767e\u5e74\u540e\uff0c\u4eba\u4eec\u53ef\u80fd\u6bcf\u5929\u90fd\u670d\u7528\u8fd9\u4e9b\u5206\u5b50\u6765\u9884\u9632\u5fc3\u810f\u75c5\u3001\u4e2d\u98ce\u3001\u8111\u90e8\u75be\u75c5\u548c\u764c\u75c7\u3002\u201d2004\u5e74\uff0c\u8f9b\u514b\u83b1\u5c14\u6536\u5230\u6148\u5584\u5bb6Paul F. Glenn\u7684500\u4e07\u7f8e\u5143\u6350\u6b3e\uff0c\u6210\u7acb\u4e86Paul F. Glenn\u8870\u8001\u751f\u7269\u673a\u5236\u5b9e\u9a8c\u5ba4\uff0c\u4ed6\u4f5c\u4e3a\u521b\u59cb\u8463\u4e8b\u5e76\u6267\u638c\u8fd9\u4e2a\u5b9e\u9a8c\u5ba4\u81f3\u4eca\u3002 \u540c\u4e00\u5e74\uff0c\u5728\u751f\u7269\u6280\u672f\u8fde\u73af\u521b\u4e1a\u5bb6Christoph Westphal\u7684\u8d44\u52a9\u4e0b\uff0c\u8f9b\u514b\u83b1\u521b\u529e\u4e86\u4e00\u5bb6\u540d\u4e3aSirtris Pharmaceuticals\u7684\u516c\u53f8\uff0c\u4ee5\u767d\u85dc\u82a6\u9187\u4e3a\u7075\u611f\u5f00\u53d1\u4e34\u5e8a\u836f\u7269\u3002\u5f53\u65f6\uff0c\u51e0\u4e4e\u6ca1\u6709\u6297\u8870\u8001\u533b\u5b66\u9886\u57df\u7684\u79d1\u5b66\u5bb6\u521b\u529e\u516c\u53f8\uff0c\u8f9b\u514b\u83b1\u5f00\u521b\u4e86\u5b66\u672f\u548c\u5546\u4e1a\u76f8\u7ed3\u5408\u7684\u5148\u6cb3\uff0c\u540e\u6765\u8fd9\u5bb6\u516c\u53f8\u57282007\u5e74\u4e0a\u5e02\uff0c\u57282008\u5e74\u4ee57.2\u4ebf\u7f8e\u5143\u7684\u4ef7\u683c\u88abGlaxoSmithKline\u6536\u8d2d\uff0c\u6210\u4e3a\u5176\u5b50\u516c\u53f8\u3002\u4e0d\u8fc7\u8fd9\u4e2a\u65f6\u671f\u6709\u5173\u767d\u85dc\u82a6\u9187\u7684\u7814\u7a76\u6210\u679c\u8fd8\u4e3b\u8981\u505c\u7559\u5728\u79d1\u5b66\u9886\u57df\uff0c\u5e76\u6ca1\u6709\u5728\u516c\u4f17\u5c42\u9762\u4ea7\u751f\u7279\u522b\u5927\u7684\u5f71\u54cd\uff0c\u4f46\u8fd9\u4e00\u5207\u57282006\u5e74\u53d1\u751f\u4e86\u5f7b\u5e95\u6539\u53d8\u3002\u8f9b\u514b\u83b1\u548cJoseph Baur\u8054\u5408\u53d1\u8868\u5728\u300a\u81ea\u7136\u300b\u4e0a\u7684\u8bba\u6587\u7684\u300a\u767d\u85dc\u82a6\u9187\u7684\u6f5c\u5728\u6cbb\u7597\uff1a\u4f53\u5185\u8bc1\u636e\u300b\uff08Therapeutic potential of resveratrol: the in vivo evidence\uff09\u5f15\u53d1\u8f70\u52a8\uff0c\u5f15\u53d1\u6570\u5341\u5bb6\u5a92\u4f53\u7684\u5173\u6ce8\uff0c\u5e76\u767b\u4e0a\u300a\u7ebd\u7ea6\u65f6\u62a5\u300b\u5934\u7248\u3002\u5a92\u4f53\u8fde\u7bc7\u7d2f\u724d\u7684\u62a5\u9053\uff0c\u52a0\u4e0a\u8f9b\u514b\u83b1\u5728\u955c\u5934\u9762\u524d\u5c55\u73b0\u51fa\u7684\u8ff7\u4eba\u98ce\u91c7\u8ba9\u4ed6\u4e00\u591c\u6210\u540d\uff0c\u4ece\u4e00\u540d\u5728\u5b9e\u9a8c\u5ba4\u91cc\u57cb\u5934\u82e6\u5e72\u7684\u79d1\u5b66\u5bb6\uff0c\u53d8\u6210\u4e86\u4e00\u4e2a\u5728\u8857\u4e0a\u968f\u65f6\u80fd\u88ab\u8ba4\u51fa\u7684\u540d\u4eba\uff0c\u6210\u4e86\u957f\u5bff\u9886\u57df\u7684\u5b97\u5e08\uff0c\u88ab\u8a89\u4e3a\u201c\u6297\u8870\u6765\u4e4b\u7236\u3002\u201d 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